Update: You can just use TQvault XL (Both IT and AE) or TQ Caravan XL (AE + Ragnarok Expansion) version that works both on Anniversary Edition and Classic Titan Quest. Much more storage space too!

Now the Titan Quest updated to the Anniversary Edition some mods and utilities are not working with it. Until the TQVault updated to the new version, here is a workaorund on how to run TQVault on the new Titan Quest Anniversary Edition:

1. Locate Titan Quest Anniversary Edition folder. “C:GamesTitan Quest – Anniversary Edition” for GOG release, “C:SteamsteamappscommonTitan Quest Anniversary Edition/” for Steam.
2. Create file named “Tqit.exe” in there. Copy Tq.exe or create new empty file – it doesn’t need to really be executable, just needs to be there.
3. Find “Text” folder, and copy it’s contents into “Resources” folder.
4. Turn off autodetection in TQ Defiler config file (as described in PDF readme) and point it at “Titan Quest Anniversary Edition” folder for both games.
5. Profit!

Source:
http://www.titanquest.net/tq-forum/threads/41212-REL-TQVault-2-3-1-x/page37?p=519419&viewfull=1#post519419

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